CNS Depressants: Neurobiology, Clinical Risks, and Treatment Considerations is a self-paced professional training designed for clinicians who want to better understand how central nervous system depressants affect brain functioning, client presentation, diagnosis, and treatment planning. CNS depressants are among the most clinically significant substances encountered in behavioral health practice. This course provides a practical, clinically relevant overview of commonly used depressants, including alcohol, benzodiazepines, opioids, and sedative-hypnotics, with attention to their pharmacological properties, patterns of use, and associated clinical risks. Participants will explore the neurobiological mechanisms of CNS depressants, including their short- and long-term physiological and psychological effects. The training also addresses tolerance, dependence, withdrawal risks, and potentially life-threatening complications that may arise when these substances are misused, discontinued abruptly, or used in combination with other substances. Clinical implications for assessment, diagnosis, and treatment are emphasized throughout the course, particularly in the context of co-occurring mental health conditions, substance use disorders, and polysubstance use. Participants will also consider applied case examples to strengthen clinical decision-making and treatment planning. This course is especially valuable for counselors, therapists, social workers, addiction professionals, and behavioral health providers working with clients who use CNS depressants recreationally, medically, or as part of a broader pattern of substance use. This self-paced course is designed to require approximately 180 minutes to complete, including review of course materials, engagement with applied case considerations, and completion of the post-test. Total instructional time has been calculated in accordance with continuing education standards for asynchronous learning.